莎拉Blumer-Schuette

莎拉Blumer-Schuette
副教授，博士.D.
331年硕士
248-370-3168
实验室位置:330 MSC
实验室电话:(248)370-4903
(电子邮件保护)
布鲁默-舒特实验室网站

课程:

生物1200生物学1
BIO 3500一般微生物学
BIO 4511 微生物生物技术 

Microbial Physiology and Genomics

Non-model environmental microorganisms are promising reservoirs of unique metabolic pathways that can be harnessed to replace traditional synthetic chemistry. Professor Blumer-Schuette’s research interests include microbial physiology and genomics of non-model microorganisms living at the extremes of life. Current projects include unraveling mechanisms used by extremophilic microbes to interact with substrates that they require as an energy source. Given the intense competition in microbial biospheres, the ability to efficiently harness energy sources, 无论是有机的还是无机的, 对微生物至关重要. Implications for understanding these mechanisms range from outlining how microbial attachment mechanisms have functionally evolved, to the environmental implications of these mechanisms and identifying targets for rational design of commercially relevant microbes. Other research interests include characterizing transport systems used to secrete large (some over 200 kDa) enzymes by monoderm bacteria, and how to optimize secretion efficiency of these systems.  在Blumer-Schuette实验室, students can expect to use a combination of anaerobic and aerobic microbiology, 功能基因组学, microbial genetics and biochemistry in their research projects.

选择出版物:

莎拉Blumer-Schuette NCBI publication list

汗,一个.M. 汗,V.J. 霍克*,米. 易卜拉欣* T.R. 拉斐尔和S.E Blumer-Schuette. (2020). Caldicellulosiruptor bescii adheres to polysaccharides using a type IV pilin-dependent mechanism. Applied and Environmental Microbiology  Posted online February 21, 2020 DOI: 10.1128 / AEM.00200-20.

汗,一个., C. 门多萨,V. Hauk*和S. Blumer-Schuette. (2019). Genomic and physiological analyses reveal that extremely thermophilic Caldicellulosiruptor changbaiensis deploys uncommon cellulose attachment mechanisms. Journal of Industrial Microbiology & 生物技术 46: 1251-1263. DOI: 10.1007/s10295-019-02222-1.

门多萨,C. 和S.E. Blumer-Schuette. (2019). 全基因组序列 Caldicellulosiruptor changbaiensis CBS-Z, 极度嗜热, cellulolytic bacterium isolated from a hot spring in China. Microbiology Resource Announcements 8: e00021-19. DOI: 10.1128 /查看.00021-19.

米切尔*，J, S.J. 金,G. Koukos,. Seelmann * B. Veit * B. 谢泼德*,年代. Blumer-Schuette H.S. 冬天,维. Iliopoulos C. Pothoulakis E. i和S.H. Rhee. (2018). Colonic inhibition of phosphatase and tensin homolog increases colitogenic bacteria, causing development of colitis in Il10-/- Mice. 炎症性肠病 24(8):1718-1732. DOI: 10.1093 / ibd / izy124. 

李,李.L., S.E. Blumer-Schuette J.A. Izquierdo J.V. Zurawski,.J. 洛德,J.M. 康威J.G. Elkins, M. Podar,. Clum P.C. 琼斯,米.J. Piatek D.A. Weighill D.A. 雅各布森,M.W.W. 亚当斯和R.米凯利. (2018). Genus-wide assessment of lignocellulose utilization in the extremely thermophilic genus Caldicellulosiruptor by genomic, pangenomic, 以及宏基因组分析. Applied Environmental Microbiology 84: e02694-17. DOI: 10.1128 / AEM.02694-17.

布卢姆高Schuette年代.E., J.V. Zurawski J.M. 康威,P. Khatibi D.L. 刘易斯,问. 李,V.L. 蒋和R.M. 凯利. (2017). Caldicellulosiruptor saccharolyticus transcriptomes reveal consequences of chemical pretreatment and genetic modification of lignocellulose. 微生物生物技术 10: 1546-1557. DOI:  10.1111/1751-7915.12494.

Blumer-Schuette,年代.E., M. 阿拉胡赫塔J.M. 康威,L.L. 李,我.V. Zurawski R.J. Giannone R.L. Hettich V.V. Lunin, M.E. 希梅尔和R.M. 凯利. (2015). Discrete and structurally unique proteins (tāpirins) mediate attachment of extremely thermophilic Caldicellulosiruptor 纤维素的种类. 生物化学杂志. DOI: 10.1074 / jbc.M115.641480.

布卢姆高Schuette年代.E., S.D. 布朗,K.B. 桑德,E.A. 拜耳,我. Kataeva J.V. Zurawski J.M. 康威,M.W.W·亚当斯和 R.M. 凯利. (2014). Thermophilic lignocellulose deconstruction. FEMS微生物学综述 38: 393-448. DOI: 10.1111/1574-6976

连衣裙,.D., C.I. 蒙特罗,年代.E. Blumer-Schuette和 R.M. 凯利. (2013). Stationary phase and nutrient levels trigger transcription of a genomic locus containing a novel peptide (TM1316) in the hyperthermophilic bacterium Thermotoga maritima. Applied and Environmental Microbiology 79: 6637-6646. DOI: 10.1128 / AEM.01627-13

Blumer-Schuette,年代.E., R.J. Giannone J.V. Zurawski,我. 奥兹德米尔,问. 马,Y. 阴,Y. 徐,我. Kataeva F.L. 普尔，M.W.W. 亚当斯,年代.D. Hamilton-Brehm J.E. Elkins F.W. 此外,M.L. 土地,L.J. 豪泽,R.W. Cottingham R.L. Hettich和 R.M. 凯利. (2012). Caldicellulosiruptor core and pangenomes reveal determinants for noncellulosomal thermophilic deconstruction of plant biomass. 细菌学杂志 194: 4015-4028. DOI: 10.1128/JB.00266-12

Blumer-Schuette,年代.E., D.L. 刘易斯和 R.M. 凯利. (2010). 系统发育, 微生物, and glycoside hydrolase diversities within the extremely thermophilic, plant biomass-degrading genus Caldicellulosiruptor. Applied and Environmental Microbiology, 76: 8084-8092. DOI: 10.1128 / AEM.01400-10.

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